FOR PERSONALIZED IMPROVEMENT OF SPORTS PERFORMANCE

PREVENTIVE GENE CONTROL (DNA test):

Predisposing genetic testing analyzes a large number of genes that have been selected from published documented scientific studies and are linked to physical performance and athletic performance..

Specifically, genetic polymorphisms associated with endurance are detected, muscle strength and performance, the speed, susceptibility to tendon and bone injuries and psychological motivation to exercise.

Genetic Test for Athletic Performance Identifies Potential Genetic Benefits, the genetic barriers that need to be overcome but also the increased risk of sports injuries.

Predisposing genomics tests, in addition to determining predisposition, enable the implementation of personalized training programs to optimize and peak performance.

Predisposing genetic testing shows the way to victory!

All genes are tested regardless of gender and age. Sampling is very easy by taking an epithelial scrap from the cheek mucosa with a cotton swab.

 

The genes we research and their effect on the areas we are interested in:

  • BODY MASS INDEX

The genes ADRB2 and ADRB1 related to the regulation of lipolysis , the production of thermal energy through metabolism (thermogenesis) and the response to asthma medications. Affects the ability to withstand prolonged physical exercise.

Even if fat metabolism is reduced, for athletes this does not significantly affect the mass-fat ratio in their body. With the appropriate training and nutrition instructions, Athletes can maintain or even increase their muscle mass, reducing fat storage.The gene ADRA2A related to blood glucose levels, fat storage as well as blood pressure. (Elevated blood glucose levels lead to increased fat storage)

With proper training and nutrition instructions, athletes can maintain or even increase their muscle mass and consequently reduce their body fat mass..

 

  • USE OF ANABOLIC SUBSTANCES

The gene UGT2B17 related to testosterone metabolism. People with abnormal genotype have significantly reduced testosterone levels in the urine. Anti-doping test thresholds should be lower for this individual!

 

  • PSYCHOLOGICAL CONDITION (MOTIVATION FOR EXERCISE)

The gene BDNF related to the mood for sports, the formation of nerve tissue and the creation of synapses. The pathological genotype is associated with decreased mood and motivation for physical exercise. Athletes need to be more psychologically active, so as to maintain positive thinking and not be overwhelmed by negative emotions, especially under stressful conditions of competition.

 

  • SENSITIVITY TO TENDENCY INJURIES

The genes COL1A1, COL5A1 related to the synthesis of collagen in bones, cartilage and skin. People with the abnormal type of the gene have a significantly increased risk

tendon injury (such as the rupture of the Achilles tendon). The risk of injury is further increased when individuals also have the defective type of MMP3 gene. The gene MMP3 related to the regulation of connective tissue degradation and injury repair.

 

  • SENSITIVITY TO BONE INJURIES

The gene VDR is related to the regulation of collagen synthesis and the synthesis and replacement of bone tissue. The pathological type of the gene is associated with disorders in the absorption of Vitamin D and calcium by the body with a negative effect on bone health.. In particular, it is associated with reduced bone density and is likely to increase the risk of bone injuries..

 

  • ATHLETIC PERFORMANCE - ENDURANCE

The gene US3 is associated with vasodilation and oxygen supply to the muscles, which is an important factor in increasing endurance

The gene EPOR is associated with the synthesis and differentiation of erythroblasts. Increased oxygen uptake by reds helps oxygenate tissues.

The gene HIF-1a associated with angiogenesis and red blood cell synthesis and tissue oxygenation. It also participates in the determination of the basic metabolic rate. People with this type of gene have an increased ability to resist. Their muscles respond well to aerobic exercise, during which local conditions of lack of oxygen are created in the muscle cells. They also respond well to high altitude training, where conditions of partial lack of oxygen prevail

The gene CHRM2 is related to the recovery of the heartbeat after exercise
The gene UK is associated with opportunities to improve endurance. After proper training in endurance exercises, Athletes can significantly reduce the amount of oxygen and energy they consume during exercise..

The gene PPARg-C1 related to the production of muscle energy. The favorable genotype shows particularly increased levels of mental endurance and reduced levels of body fat. Individuals with this genetic profile have increased transport and utilization of oxygen for energy production by the two during physical exercise.. Athletes show increased performance in endurance sports.

The gene VEGF associated with angiogenesis and tissue oxygenation. The pathological genotype is associated with reduced potential in endurance sports, due to the limited supply of oxygen to the muscles in the long-term physical exercise.

The gene CK-MM related to energy consumption by muscles. People with the abnormal gene type have a significant disadvantage when they perform mental exercises with increased intensity and/the duration. Their mental system consumes particularly high amounts of energy resulting in particularly increased fatigue of the Muscles after exercise.

The gene ACTN3 associated with rapid muscle contraction.

The gene ACE related to muscular physique, the regulation of blood pressure, and with blood glucose and lipid levels. In a pathological genotype, performance in endurance sports is reduced.

NUTRITIONAL INSTRUCTIONS- SUPPLEMENTS - ELECTROLYTES

  • ATHLETIC PERFORMANCE - MUSCLE PERFORMANCE

The gene ACE associated with muscular physique, the regulation of blood pressure, and with blood glucose and lipid levels. The favorable genotype gives athletes a particularly increased muscular strength. The pathological type is associated with an increased chance of muscle injuries especially when the athlete has elevated CK levels (creatinine kinase) in the blood.

The gene ACTN3 associated with rapid muscle contraction. Favorable genotype gives athletes a significant advantage in sports that require strength and / or speed. Their Souls contract quickly, allowing ‘explosive’ starts.

The gene IT GAVE1 is related to the regulation of thyroid hormones and muscle strength.

The gene MCT-1 is associated with the removal of lactic acid and muscle fatigue. At low levels of lactic acid removal, Athletes are sensitive to muscle fatigue that occurs during or even after intense physical exercise, which can occur in Mental Conditions or even Mental Injuries.

The gene HIF-1a . Favorable genotype is associated with increased performance in mental strength exercises, because they show increased energy production from glucose (anaerobic metabolism). Athletes recover relatively quickly from mental injuries

The gene US3 related to muscle performance. The favorable genotype shows increased mental strength, due to the increased growth of the Mental system. The genetic profile of these individuals contributes to the increased energy production by the Forces during exercise., As a result of the reduction of the fat mass in their body. Athletes recover relatively quickly from mental injuries

The gene AMPD1 related to Mental performance and endurance, regardless of the sport in which they are involved.

 

  • ANTIOXIDANT ACTION AND DETOXIFICATION

The gene CAT is associated with antioxidant protection and neutralization of free radicals. At increased enzyme activity of the gene there is a reduced risk compared to the general population for the development of cancer (0,83x), while in combination with fruit consumption the risk is further reduced (0,59x). The genes, SALTS, SOD3are also associated with antioxidant protection of skin cells. The gene GPX1 associated with cellular aging, detoxification and antioxidant capacity. The gene SOD2 is associated with protection against oxygen free radicals and the risk of cell damage due to increased oxidative stress. The gene UCP2 associated with antioxidant activity. Improved protection against free radicals leads to increased cell damage, especially when people follow a diet low in antioxidants.

The genotype is also associated with metabolic disorders and the development of insulin resistance., as the corresponding enzyme is involved in the regulation of leptin and in the regulation of food intake. The presence of polymorphism in combination with polymorphisms in the IL-6 gene is associated with weight gain over time.

The gene EPHX1 associated with the metabolism of xenobiotic and pro-carcinogenic compounds to carcinogens. Associated with protection against environmental toxins, especially those found in car exhaust, Cigarette smoke and charcoal smoke used for cooking purposes. In a pathological genotype we have a higher risk for chronic obstructive pulmonary disease and various forms of cancer.

 

  • LIPID METABOLISM genes are involved APOA5, APOC3, ΑΡΟΒ, LIPC which are related to lipid metabolism. People with abnormal APOA5 genotype have elevated blood lipid levels and are at increased risk. (1,4x) in relation to the general population for heart attack. The genes APOC3 and LPL related to triglyceride metabolism. The pathological genotype of LPL is associated with elevated levels of VLDL in the blood, especially in people who consume a lot of animal fats in their diet.. The gene APOA1related to the rate at which lipids are removed from the bloodstream (protection of the cardiovascular system)

The gene ΡΟΝ1 is related to the regulation of HDL cholesterol. Its abnormal expression leads to an increased risk of elevated LDL and low HDL levels in the blood. This carries an increased risk of atherosclerosis and cardiovascular disease. particularly, diabetics are at increased risk (8,8x) for carotid atherosclerosis.

The gene CETP related to the synthesis of HDL cholesterol ("Good cholesterol") but also with the transport capacity of HDL. Also the gene LIPC is also associated with a predisposition to type II diabetes.

 

 

  • the ADJUSTMENT OF HOMOCYSTINE LEVELS : The gene TNC2 (C776 / G polymorphism) and MTR and MTRRrelated to the regulation of oocysteine ​​levels in the blood. The gene MTHFR is involved in the metabolism of folic acid and the regulation of oocysteine ​​levels in the blood. In reduced functionality of MTHFR we have an increased predisposition for high levels of oocysteine ​​in the blood. When the abnormal genotype is associated with elevated homocysteine ​​levels (risk of cardiovascular disease-coronary heart disease) It is good to enhance our diet with foods rich in B-complex vitamins (folic acid, B6, B12).

 

 

  • INFLAMMATIVE RESPONSE AND OBESITY

The gene THE6 related to glucose metabolism. The abnormal genotype is associated with reduced use of glucose by the body and reduced energy production by it. This results in an increase in glucose stores, inhibition of lipolysis and reduction of fatty acid oxidation. An increase in blood glucose causes insulin resistance, characteristic of the Metabolic Syndrome that gradually leads to obesity. Carriers have an increased risk relative to the general population for a higher BMI.

Polymorphism is a predisposing indicator for abdominal obesity and parameters of glucose and insulin homeostasis. particularly, obese carriers show a greater increase in IL6 levels, are five times more likely to develop type II diabetes and 5, twice as high risk of obesity-related diseases as carriers of other alleles. The IL-6 gene is also associated with the inflammatory response

The gene TNF-a associated with the inflammatory response and insulin response.
The gene CRP associated with the inflammatory response. In abnormal genotype we have increased CRP levels associated with increased BMI and a low fat diet is recommended

 

Results

The test results are easily understood as the effect of each genotype is described with color bars, in which the green color indicates the existence of a genetic advantage for each accompanying gene, yellow means the neutral expression of the gene without any effect on the body and red indicates an increased risk associated with the occurrence of damage to the biological system. The genotypes corresponding to the green and yellow color of the bar do not require corrective movement. However, those that correspond to the red color of the bar need corrective moves.

also, in the "interpretations of the results" the final conclusion concerning each gene category comes out depending on the severity of each negative genotype. This means that it is possible even though the green markings on each bar are many times larger than the red ones., the gene profile for these genes may indicate increased risk and vulnerability.

Example result for gene:

Example result for gene

 

GLOSSARY

  • DNA is located in the nucleus of the cell and is the carrier of genetic information, not only in the sense of feature transfer, but also the specialization of each cell to perform its particular functions.
  • The Gene represents a small part of DNA and is responsible for the synthesis of specific substances or the expression of a specific trait (e.g. Eye colour). The human body has 30-50 thousands of genes.
  • Mutation is a variation of the DNA sequence, where a nucleotide in one gene has been altered by another. The profile of mutations in different genes can determine the chances of developing diseases and health disorders.

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